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Expanded Outpatient COVID Treatment (Paxlovid, Sotrovimab) Use Criteria

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Please see below for expanded outpatient COVID-19 treatment (Paxlovid, Sotrovimab) use criteria. The EPIC order entry will be updated by 2/9/2022. See attached PDF for full prescribing and referral process.

KH Pharmacy and Therapeutics (P&T) Criteria for Use:
Patient must meet ALL of the following criteria:
Positive test for SARS-CoV-2
Onset of symptoms within the past 7 days
Patient is 18 years of age or older
Patient does not require supplemental oxygen or there is no increase in baseline oxygen needs

AND

One (1) of the following:
Pregnancy
Active Cancer
Hematologic malignancy
Immunocompromised (On biologic agents, high dose chronic steroids, B-cell depleting therapy, TK inhibitors*, primary immunodeficiency, etc)
HIV Patients
Solid organ transplant recipients
Hematopoietic cell transplant recipients
Graft-versus-host disease
Chimeric antigen receptor T-cell recipients (CAR T-Cell Therapy) (Idecabtagene Vicleucel, Brexucabtagene Autoleucel, Axicabtagene Ciloleucel, Axicabtagene Ciloleucel)
Age ≥ 65 years
Not fully vaccinated per CDC definition
BMI ≥ 35
Cardiovascular Disease: Hypertension, Coronary Artery Disease or Congestive Heart Failure
Diabetes Mellitus (on insulin therapy or oral hypoglycemics)
Chronic Lung Disease: COPD, Asthma, Interstitial Lung Disease, Cystic Fibrosis, or Pulmonary Fibrosis
Chronic Kidney Disease (stage 4 and above, ESRD)
End stage liver disease
Neurodevelopmental disorders (Ex. Cerebral palsy)
Medical-related technological dependence (Ex. Tracheostomy, gastrostomy, etc.)
Sickle Cell disease

February 8, 2022
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