Remdesivir – Duration limited to 5 days
Patients must have all of these:
1. Early disease, 10 days or less from beginning of symptoms or positive test (whichever comes first), not hospitalization
2. Hypoxemia, which is a drop of O2 sat to 93% or lower on RA, or a sustained increase in baseline oxygen needs, if on chronic oxygen
Patients must not have any of these:
1. Previous remdesivir therapy within the past 12 months
2. Severe disease, as evidenced by ARDS, MOSF, ECMO, or intubated more than 7 days
3. AST/ALT > 10 times upper limit of normal (about 500)
4. eGFR < 30 or dialysis
Convalescent Plasma – Maximum 2 units, no repeat dosing
Patients must have all of these:
1. Early disease, 5 days or less from beginning of symptoms or positive test (whichever is first), not hospitalization
2. Hypoxemia, which is a drop of O2 sat to 93% or lower on RA, or a sustained increase in baseline oxygen needs, if on chronic oxygen
3. Must have a positive SARS-CoV-2 test
Use of these modalities will continue to be audited. Please do not deviate from these guidelines without literature-based indications.